A coassembled peptide hydrogel boosts the radiosensitization of cisplatin

Chem Commun (Camb). 2020 Oct 27;56(85):13017-13020. doi: 10.1039/d0cc05184e.

Abstract

We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt-DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.

MeSH terms

  • A549 Cells
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Cycle Checkpoints / drug effects
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Cyclooxygenase 2 / metabolism*
  • Cyclooxygenase 2 Inhibitors / chemistry
  • Cyclooxygenase 2 Inhibitors / pharmacology*
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydrogels / chemistry*
  • Molecular Structure
  • Peptides / chemistry*
  • Radiation-Sensitizing Agents / chemistry
  • Radiation-Sensitizing Agents / pharmacology*

Substances

  • Antineoplastic Agents
  • Cyclooxygenase 2 Inhibitors
  • Hydrogels
  • Peptides
  • Radiation-Sensitizing Agents
  • Cyclooxygenase 2