A Rare Case of Cerebellar Progressive Multifocal Leukoencephalopathy due to Idiopathic CD4 Lymphocytopenia

Paige Sutton; Flavius Raslau; Padmaja Sudhakar

doi:10.1016/j.msard.2020.102531

A Rare Case of Cerebellar Progressive Multifocal Leukoencephalopathy due to Idiopathic CD4 Lymphocytopenia

Mult Scler Relat Disord. 2020 Nov:46:102531. doi: 10.1016/j.msard.2020.102531. Epub 2020 Sep 24.

Authors

Paige Sutton¹, Flavius Raslau², Padmaja Sudhakar²

Affiliations

¹ Neurology, 740 S. Limestone, J-455, Lexington, KY 40536, United States. Electronic address: paigesutton@uky.edu.
² Neurology, 740 S. Limestone, J-455, Lexington, KY 40536, United States.

PMID: 33002678
DOI: 10.1016/j.msard.2020.102531

Abstract

Progressive multifocal leukoencephalopathy (PML) is a demyelinating disorder caused by reactivation of JC virus during a time of cell mediated immune suppression. One potential rare cause of PML is Idiopathic CD4 lymphocytopenia (ICL) in which there is an unexplained deficit of CD4 T cells. We present a case of cerebellar PML in the absence of known immunosuppression leading to the diagnosis of ICL.

Publication types

Case Reports
Letter

MeSH terms

CD4-Positive T-Lymphocytes
Cerebellum
Humans
JC Virus*
Leukoencephalopathy, Progressive Multifocal* / diagnostic imaging
T-Lymphocytopenia, Idiopathic CD4-Positive* / complications
T-Lymphocytopenia, Idiopathic CD4-Positive* / diagnostic imaging