Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

Catherine W Cai; Suteeraporn Pinyakorn; Eugène Kroon; Mark de Souza; Donn J Colby; Tippawan Pankam; Supanit Pattanachaiwit; Sasiwimol Ubolyam; Adam Rupert; Perrine Lallemand; Robin Dewar; Helene C Highbarger; Jintanat Ananworanich; Sandhya Vasan; Irini Sereti

doi:10.1093/ofid/ofaa383

Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

Open Forum Infect Dis. 2020 Aug 26;7(9):ofaa383. doi: 10.1093/ofid/ofaa383. eCollection 2020 Sep.

Authors

Catherine W Cai¹, Suteeraporn Pinyakorn^{2

3}, Eugène Kroon⁴, Mark de Souza^{2

4}, Donn J Colby^{2

3

4}, Tippawan Pankam⁵, Supanit Pattanachaiwit⁵, Sasiwimol Ubolyam⁶, Adam Rupert⁷, Perrine Lallemand⁷, Robin Dewar⁷, Helene C Highbarger⁷, Jintanat Ananworanich^{2

3

4}, Sandhya Vasan^{2

3}, Irini Sereti¹

Affiliations

¹ HIV Pathogenesis Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
² Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
³ US Military Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
⁴ South East Asia Research Collaboration in HIV (SEARCH), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
⁵ Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
⁶ The HIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
⁷ Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

Abstract

Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH.

Keywords: AIDS; HIV; chronic inflammation; coagulopathy; viral reservoir.

Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.

Abstract

Grants and funding