In Utero Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Isabelle Von Kohorn; Sydney R Stein; Beatrix T Shikani; Marcos J Ramos-Benitez; Kevin M Vannella; Stephen M Hewitt; David E Kleiner; Julie C Alejo; Peter Burbelo; Jeffrey I Cohen; Bernhard L Wiedermann; Daniel S Chertow

doi:10.1093/jpids/piaa127

In Utero Severe Acute Respiratory Syndrome Coronavirus 2 Infection

J Pediatric Infect Dis Soc. 2020 Dec 31;9(6):769-771. doi: 10.1093/jpids/piaa127.

Authors

Isabelle Von Kohorn^{1

2}, Sydney R Stein^{3

4}, Beatrix T Shikani¹, Marcos J Ramos-Benitez^{3

4}, Kevin M Vannella^{3

4}, Stephen M Hewitt^{5

6}, David E Kleiner^{5

6}, Julie C Alejo⁶, Peter Burbelo⁷, Jeffrey I Cohen⁸, Bernhard L Wiedermann^{2

9}, Daniel S Chertow^{3

4}

Affiliations

¹ Department of Pediatrics, Holy Cross Health, Silver Spring, Maryland, USA.
² Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
³ Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
⁴ Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
⁵ Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA.
⁶ Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
⁷ National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.
⁸ Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
⁹ Division of Infectious Diseases, Children's National Hospital, Washington, DC, USA.

Abstract

Evidence for in utero transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is growing but not definitive. We present a case of neonatal infection that supports in utero transmission of SARS-CoV-2 and provides insight into the hematogenous spread from mother to fetus.

Keywords: COVID-19; cord blood; neonatal; vertical transmission.

© The Author(s) 2020. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Publication types

Case Reports

MeSH terms

COVID-19 / complications
COVID-19 / transmission*
COVID-19 Testing
Female
Fetal Blood / virology
Humans
Infant, Newborn
Infant, Newborn, Diseases / diagnosis
Infant, Newborn, Diseases / etiology
Infant, Newborn, Diseases / virology*
Infectious Disease Transmission, Vertical*
Male
Placenta / virology
Pregnancy
Pregnancy Complications, Infectious / virology*
RNA, Viral / blood
RNA, Viral / urine
SARS-CoV-2 / genetics

Substances

RNA, Viral