Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer

Neurosurgery. 2021 Jan 13;88(2):234-245. doi: 10.1093/neuros/nyaa455.

Abstract

In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.

Keywords: Malignant peripheral nerve sheath tumor; NF1; NF2; Neural crest; Neurofibroma; Schwann cell; Schwannoma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / physiology
  • Cell Transformation, Neoplastic* / genetics
  • Cell Transformation, Neoplastic* / pathology
  • Humans
  • Mice
  • Neural Crest / embryology*
  • Neurogenesis / physiology*
  • Peripheral Nervous System Neoplasms* / genetics
  • Peripheral Nervous System Neoplasms* / pathology
  • Schwann Cells*
  • Signal Transduction / physiology