Quantification of Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Protein Expression in Bone Biopsies by Targeted Mass Spectrometry without Acid Decalcification

Clin Chem. 2020 Nov 1;66(11):1459-1461. doi: 10.1093/clinchem/hvaa220.
No abstract available

Keywords: Bone metastasis; Breast cancer biomarkers; Decalcification; ER; HER2; Immunopeptide enrichment; Multiple reaction monitoring-mass spectrometry; PR.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Biopsy, Needle
  • Bone Neoplasms / secondary
  • Bone and Bones / pathology
  • Breast Neoplasms / pathology
  • Humans
  • Mass Spectrometry / methods
  • Proof of Concept Study
  • Receptor, ErbB-2 / analysis*
  • Receptors, Estrogen / analysis*
  • Receptors, Progesterone / analysis*

Substances

  • Biomarkers, Tumor
  • Receptors, Estrogen
  • Receptors, Progesterone
  • ERBB2 protein, human
  • Receptor, ErbB-2