MTORC1 and the Rebirth of Stemness

Nicolette M Johnson; Christopher J Lengner

doi:10.1016/j.devcel.2020.10.001

MTORC1 and the Rebirth of Stemness

Dev Cell. 2020 Oct 26;55(2):113-115. doi: 10.1016/j.devcel.2020.10.001.

Authors

Nicolette M Johnson¹, Christopher J Lengner²

Affiliations

¹ Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Medical Scientist Training Program, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Cell & Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: lengner@vet.upenn.edu.

PMID: 33108751
DOI: 10.1016/j.devcel.2020.10.001

Abstract

MTORC1 activity is critical for tissue regeneration in multiple organs and contexts. In this issue of Developmental Cell, Miao et al. describe upstream regulators of mTORC1 activity which promote paligenosis, a process where mature cells de-differentiate to acquire stem cell activity in the face of injury.

Publication types

Comment

MeSH terms

Extracellular Vesicles*
Mechanistic Target of Rapamycin Complex 1
Mitochondrial Dynamics
Stem Cells
Tumor Microenvironment*

Substances

Mechanistic Target of Rapamycin Complex 1

Grants and funding

R01 DK106309/DK/NIDDK NIH HHS/United States