Subtle immunodeficiencies in nodular-bronchiectatic Mycobacterium avium complex lung disease

Mariolina Bruno; Sanne M H Zweijpfenning; Jeske Verhoeven; Martin J Boeree; Mihai G Netea; Frank L van de Veerdonk; Jakko van Ingen; Wouter Hoefsloot

doi:10.1183/23120541.00548-2020

Subtle immunodeficiencies in nodular-bronchiectatic Mycobacterium avium complex lung disease

ERJ Open Res. 2020 Oct 19;6(4):00548-2020. doi: 10.1183/23120541.00548-2020. eCollection 2020 Oct.

Authors

Mariolina Bruno¹, Sanne M H Zweijpfenning², Jeske Verhoeven², Martin J Boeree², Mihai G Netea^{1

3}, Frank L van de Veerdonk¹, Jakko van Ingen⁴, Wouter Hoefsloot²

Affiliations

¹ Dept of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
² Radboudumc Center for Infectious Diseases, Dept of Pulmonary Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Dept for Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
⁴ Radboudumc Center for Infectious Diseases, Dept of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.

Abstract

Patients with nodular-bronchiectatic MAC lung disease have dysregulated adaptive immunity with defective IL-17 and IFN-γ production, and IL-10 overproduction. This suggests a role for adjunctive immunomodulatory treatments. https://bit.ly/33AALwx.