High-resolution impedance manometry and 24-hour multichannel intraluminal impedance with pH testing before and after sleeve gastrectomy: de novo reflux in a prospective series

Tien Yew Chern; Daniel L Chan; Jason Maani; Jorgen S Ferguson; Michael L Talbot

doi:10.1016/j.soard.2020.09.030

High-resolution impedance manometry and 24-hour multichannel intraluminal impedance with pH testing before and after sleeve gastrectomy: de novo reflux in a prospective series

Surg Obes Relat Dis. 2021 Feb;17(2):329-337. doi: 10.1016/j.soard.2020.09.030. Epub 2020 Sep 23.

Authors

Tien Yew Chern¹, Daniel L Chan², Jason Maani³, Jorgen S Ferguson³, Michael L Talbot⁴

Affiliations

¹ Upper Gastrointestinal Surgery, St George Private Hospital, Sydney, Australia; Faculty of Medicine, Department of Surgery, University of New South Wales, Sydney, Australia. Electronic address: Tienyew.Chern@health.nsw.gov.au.
² Upper Gastrointestinal Surgery, St George Private Hospital, Sydney, Australia; Faculty of Medicine, Department of Surgery, University of New South Wales, Sydney, Australia; Faculty of Medicine, Western Sydney University, Sydney, Australia.
³ Upper Gastrointestinal Surgery, St George Private Hospital, Sydney, Australia.
⁴ Upper Gastrointestinal Surgery, St George Private Hospital, Sydney, Australia; Faculty of Medicine, Department of Surgery, University of New South Wales, Sydney, Australia.

PMID: 33153961
DOI: 10.1016/j.soard.2020.09.030

Abstract

Background: Laparoscopic sleeve gastrectomy (SG) is increasingly popular but concern regarding its effect on gastroesophageal reflux disease remain. The current literature is conflicting, and there have been little objective data.

Objectives: To objectively and more accurately assess the impact of SG on esophago-gastric physiology.

Setting: Centre of Excellence in Metabolic and Bariatric Surgery, Private Hospital, Australia.

Methods: Prospective cohort study of 31 patients undergoing SG with high-resolution impedance manometry (HRM), 24-hour multichannel intraluminal impedance combined with pH testing (MII-pH), and Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) questionnaire 1 month before and 6 months after SG.

Results: There were 31 patients that underwent SG, 20 with synchronous hiatal repair and fixation, and 6 that were excluded. HRM demonstrated significantly increased intragastric pressures (15.5-29.6 mm Hg) and failed swallows (3.1-7.5%) but no other change in esophageal motility. MII-pH did not demonstrate significant changes in acid exposure time (8.5%-7.5%) or number of reflux episodes, although the numbers of long reflux episodes (2.3-4.7) and weak acid reflux episodes were significantly increased (15.4-55.2). DeMeester and GSAS scores were not significantly changed. There was no significant difference in patients with preexisting reflux. However, for patients without preexisting reflux, acid exposure time increased significantly (1.3%-6.7%), as did DeMeester scores (5.8-24.5) and the numbers of long reflux episodes (.1-4.4) and weakly acidic episodes (22.1-89.2).

Conclusion: SG was associated with increased intragastric pressures, without changes in esophageal motility or acid exposure. For patients without preexisting reflux, there were increases in acid exposure time, long reflux episodes, weakly acidic reflux episodes, and DeMeester score.

Keywords: Bariatric surgery; Gastroesophageal reflux; MII-pH; Manometry; Obesity; Sleeve gastrectomy.

MeSH terms

Australia
Electric Impedance
Esophageal pH Monitoring
Gastrectomy
Gastroesophageal Reflux* / diagnosis
Gastroesophageal Reflux* / etiology
Humans
Hydrogen-Ion Concentration
Manometry
Prospective Studies