Use of Relative Molar Sensitivity as a Specific Value for Evaluating Heptaoxyethylene Dodecyl Ether Concentrations in Methanol Solution

Miho Kuroe; Masahiko Numata; Naoko Masumoto; Yuzo Nishizaki; Naoki Sugimoto; Nobuyasu Itoh

doi:10.2116/analsci.20N031

Use of Relative Molar Sensitivity as a Specific Value for Evaluating Heptaoxyethylene Dodecyl Ether Concentrations in Methanol Solution

Anal Sci. 2021 Jun 10;37(6):917-919. doi: 10.2116/analsci.20N031. Epub 2020 Nov 20.

Authors

Miho Kuroe¹, Masahiko Numata¹, Naoko Masumoto², Yuzo Nishizaki², Naoki Sugimoto², Nobuyasu Itoh¹

Affiliations

¹ Research Institute for Material and Chemical Measurement, National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST).
² Division of Food Additives, National Institute of Health Sciences.

PMID: 33229820
DOI: 10.2116/analsci.20N031

Abstract

Relative molar sensitivity (RMS) determined using quantitative ¹H NMR and HPLC with a refractive index (RI) detector was applied as a specific value for quantifying the levels of heptaoxyethylene dodecyl ether (HOEDE), a typical non-ionic surfactant, in methanol solutions. RMS was robust against changes of the analytical conditions (i.e., RI cell temperature, acetonitrile content in the mobile phase, HPLC system). Furthermore, the obtained HOEDE concentrations using a previously evaluated RMS were comparable to those obtained using a reference method for over 1 year.

Keywords: HPLC; RI detector; Relative molar sensitivity (RMS); heptaoxyethylene dodecyl ether (HOEDE); qNMR.