GATA3 rs3824662A allele in B-cell acute lymphoblastic leukemia in adults, adolescents and young adults: association with CRLF2 rearrangement and poor prognosis

Am J Hematol. 2021 Mar 1;96(3):E71-E74. doi: 10.1002/ajh.26065. Epub 2020 Dec 24.

Authors

Affiliations

¹ Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, Duarte, California, USA.
² Department of Hematology/Oncology, Guangzhou Women and Children's Medical Center, Guangzhou, China.
³ Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁴ Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁵ Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

PMID: 33275800
DOI: 10.1002/ajh.26065

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Alleles
Antineoplastic Combined Chemotherapy Protocols / administration & dosage
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Asparaginase / administration & dosage
Cyclophosphamide / administration & dosage
Dexamethasone / administration & dosage
Doxorubicin / administration & dosage
Female
Follow-Up Studies
GATA3 Transcription Factor / genetics*
Genetic Association Studies
Genetic Predisposition to Disease
Germ-Line Mutation
Hispanic or Latino / genetics
Humans
Kaplan-Meier Estimate
Male
Polymorphism, Single Nucleotide*
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / ethnology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / mortality
Prognosis
Receptors, Cytokine / genetics*
Risk Factors
Vincristine / administration & dosage
Young Adult

Substances

CRLF2 protein, human
GATA3 Transcription Factor
GATA3 protein, human
Receptors, Cytokine
Vincristine
Dexamethasone
Doxorubicin
Cyclophosphamide
Asparaginase

Supplementary concepts

CVAD protocol