Making a melanoma: Molecular and cellular changes underlying melanoma initiation

Revati Darp; Craig Ceol

doi:10.1111/pcmr.12950

Making a melanoma: Molecular and cellular changes underlying melanoma initiation

Pigment Cell Melanoma Res. 2021 Mar;34(2):280-287. doi: 10.1111/pcmr.12950. Epub 2021 Jan 8.

Authors

Revati Darp^{1

2}, Craig Ceol^{1

2}

Affiliations

¹ Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, USA.
² Department of Molecular, Cellular and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA.

PMID: 33283422
DOI: 10.1111/pcmr.12950

Abstract

Melanoma arises from the melanocyte lineage and is the most aggressive and lethal form of skin cancer. There are several genetic, genomic, and cellular changes associated with melanoma initiation. Here, we discuss these alterations and the melanoma cells of origin in which they are proposed to promote melanomagenesis.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Animals
Carcinogenesis / genetics
Carcinogenesis / metabolism
Carcinogenesis / pathology*
Gene Expression Regulation, Neoplastic*
Humans
Melanocytes / metabolism
Melanocytes / pathology*
Melanoma / genetics
Melanoma / metabolism
Melanoma / pathology*
Skin Neoplasms / genetics
Skin Neoplasms / metabolism
Skin Neoplasms / pathology*