Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study

Andrei Manoliu; Ronald Sladky; Sigrid Scherpiet; Lutz Jäncke; Matthias Kirschner; Amelie Haugg; Julia Bolsinger; Rainer Kraehenmann; Philipp Stämpfli; Frank Scharnowski; Uwe Herwig; Erich Seifritz; Annette B Brühl

doi:10.1177/0269881120972341

Dopaminergic neuromodulation has no detectable effect on visual-cue induced haemodynamic response function in the visual cortex: A double-blind, placebo-controlled functional magnetic resonance imaging study

J Psychopharmacol. 2021 Jan;35(1):100-102. doi: 10.1177/0269881120972341. Epub 2020 Dec 13.

Authors

Andrei Manoliu^{1

2}, Ronald Sladky^{1

3}, Sigrid Scherpiet¹, Lutz Jäncke⁴, Matthias Kirschner^{1

5}, Amelie Haugg¹, Julia Bolsinger¹, Rainer Kraehenmann¹, Philipp Stämpfli¹, Frank Scharnowski^{1

6

7}, Uwe Herwig^{1

8}, Erich Seifritz¹, Annette B Brühl^{1

9}

Affiliations

¹ Department of Psychiatry, Psychotherapy and Psychosomatics, University of Zurich, Zurich, Switzerland.
² Wellcome Centre for Human Neuroimaging, University College London, London, UK.
³ Social, Cognitive and Affective Neuroscience (SCAN) Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria.
⁴ Psychological Institute, University of Zurich, Zurich, Switzerland.
⁵ Montreal Neurological Institute, McGill University, Montreal, Canada.
⁶ Neuroscience Center Zürich, University of Zürich, Zurich, Switzerland.
⁷ Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna, Vienna, Austria.
⁸ Psychiatrisches Zentrum Appenzell Ausserrhoden, Herisau, Switzerland.
⁹ Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

PMID: 33307959
DOI: 10.1177/0269881120972341

Abstract

The aim of this study was to investigate the effect of acute dopamine agonistic and antagonistic manipulation on the visual-cue induced blood oxygen level-dependent signal response in healthy volunteers. Seventeen healthy volunteers in a double-blind placebo-controlled cross-over design received either a dopamine antagonist, agonist or placebo and underwent functional magnetic resonance imaging. Using classical inference and Bayesian statistics, we found no effect of dopaminergic modulation on properties of visual-cue induced blood oxygen level-dependent signals in the visual cortex, particularly on distinct properties of the haemodynamic response function (amplitude, time-to-peak and width). Dopamine-related effects modulating the neurovascular coupling in the visual cortex might be negligible when measured via functional magnetic resonance imaging.

Keywords: Dopamine; blood oxygen level-dependent; haemodynamic response function.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cross-Over Studies
Cues
Dopamine Agents / pharmacology
Dopamine Agonists / pharmacology*
Dopamine Antagonists / pharmacology*
Double-Blind Method
Female
Healthy Volunteers
Hemodynamics / drug effects*
Humans
Magnetic Resonance Imaging / methods*
Male
Neurotransmitter Agents / pharmacology
Photic Stimulation / methods
Visual Cortex* / blood supply
Visual Cortex* / diagnostic imaging
Visual Cortex* / drug effects

Substances

Dopamine Agents
Dopamine Agonists
Dopamine Antagonists
Neurotransmitter Agents