BKC-2, a New BKC Variant Detected in MCR-9.1-Producing Enterobacter hormaechei subsp. xiangfangensis

Antimicrob Agents Chemother. 2021 Feb 17;65(3):e01193-20. doi: 10.1128/AAC.01193-20. Print 2021 Feb 17.

Abstract

We characterized a multidrug-resistant (MDR) Enterobacter spp. isolate highlighting the genetic aspects of the antimicrobial resistance genes. An Enterobacter spp. isolate (Ec61) was recovered in 2014 from a transtracheal aspirate sample from a patient admitted to a Brazilian tertiary hospital and submitted to further microbiological and genomic characterization. Ec61 was identified as Enterobacter hormaechei subsp. xiangfangensis strain ST451, showing an MDR profile and the presence of genes codifying the new β-lactamase variants BKC-2 and ACT-84 and the mobile colistin resistance gene mcr-9.1.

Keywords: antimicrobial resistance; carbapenemase; phosphoethanolamine transferase; plasmids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Brazil
  • Colistin* / pharmacology
  • Enterobacter* / genetics
  • Humans
  • Plasmids
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • beta-Lactamases
  • Colistin

Supplementary concepts

  • Enterobacter hormaechei