Role of microRNAs in the pathophysiology of addiction

Wiley Interdiscip Rev RNA. 2021 May;12(3):e1637. doi: 10.1002/wrna.1637. Epub 2020 Dec 17.

Abstract

Addiction is a chronic and relapsing brain disorder characterized by compulsive seeking despite adverse consequences. There are both heritable and epigenetic mechanisms underlying drug addiction. Emerging evidence suggests that non-coding RNAs (ncRNAs) such as microRNAs (miRNAs), long non-coding RNAs, and circular RNAs regulate synaptic plasticity and related behaviors caused by substances of abuse. These ncRNAs modify gene expression and may contribute to the behavioral phenotypes of addiction. Among the ncRNAs, the most widely researched and impactful are miRNAs. The goal in this systematic review is to provide a detailed account of recent research involving the role of miRNAs in addiction. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions RNA in Disease and Development > RNA in Disease.

Keywords: addiction; epigenetic; microRNA; non-coding RNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Review
  • Systematic Review

MeSH terms

  • Behavior, Addictive / genetics*
  • Gene Expression
  • Humans
  • MicroRNAs* / genetics
  • RNA, Circular
  • RNA, Long Noncoding*
  • RNA, Untranslated

Substances

  • MicroRNAs
  • RNA, Circular
  • RNA, Long Noncoding
  • RNA, Untranslated