Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1339-1357. doi: 10.1161/ATVBAHA.120.315206. Epub 2020 Dec 24.

Abstract

[Figure: see text].

Keywords: DNA damage; aging; apoptosis; poly ADP ribosylation; vascular calcification.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis*
  • Cells, Cultured
  • Cellular Reprogramming*
  • Core Binding Factor Alpha 1 Subunit / genetics
  • Core Binding Factor Alpha 1 Subunit / metabolism*
  • DNA Damage*
  • Disease Models, Animal
  • Female
  • Histones / metabolism
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle, Smooth, Vascular / metabolism*
  • Muscle, Smooth, Vascular / pathology
  • Myocytes, Smooth Muscle / metabolism*
  • Myocytes, Smooth Muscle / pathology
  • Osteogenesis*
  • Phosphorylation
  • Rats
  • Rats, Wistar
  • Signal Transduction
  • Vascular Calcification / genetics
  • Vascular Calcification / metabolism*
  • Vascular Calcification / pathology

Substances

  • Core Binding Factor Alpha 1 Subunit
  • H2AX protein, human
  • H2AX protein, mouse
  • Histones
  • RUNX2 protein, human
  • Runx2 protein, mouse
  • Runx2 protein, rat