Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

Stefania Arasi; Ulugbek Nurmatov; Paul J Turner; Ignacio J Ansotegui; Shahd Daher; Audrey Dunn-Galvin; Motohiro Ebisawa; Philippe Eigenmann; Montserrat Fernandez-Rivas; Ruchi Gupta; Anna Nowak-Wegrzyn; Stavros Petrou; Graham Roberts; Mario A Sánchez Borges; Sayantani B Sindher; Luciana Kase Tanno; Marta Vazquez-Ortiz; Brian P Vickery; Gary Wing-Kin Wong; Alessandro Fiocchi

doi:10.1016/j.waojou.2020.100493

Consensus on DEfinition of Food Allergy SEverity (DEFASE): Protocol for a systematic review

World Allergy Organ J. 2020 Dec 19;13(12):100493. doi: 10.1016/j.waojou.2020.100493. eCollection 2020 Dec.

Authors

Stefania Arasi¹, Ulugbek Nurmatov², Paul J Turner^{3

4}, Ignacio J Ansotegui⁵, Shahd Daher⁶, Audrey Dunn-Galvin⁷, Motohiro Ebisawa⁸, Philippe Eigenmann⁹, Montserrat Fernandez-Rivas¹⁰, Ruchi Gupta¹¹, Anna Nowak-Wegrzyn^{12

13}, Stavros Petrou⁶, Graham Roberts^{14

15

16}, Mario A Sánchez Borges¹⁷, Sayantani B Sindher^{18

19}, Luciana Kase Tanno^{20

21}, Marta Vazquez-Ortiz²², Brian P Vickery²³, Gary Wing-Kin Wong²⁴, Alessandro Fiocchi¹

Affiliations

¹ Predictive and Preventive Medicine Research Unit, Multifactorial and Systemic Diseases Research Area, Pediatric Allergology Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.
² Division of Population Medicine, School of Medicine, Cardiff University, Wales, UK.
³ National Heart & Lung Institute, Imperial College London, London, UK.
⁴ Discipline of Paediatrics and Child Health, School of Medicine, University of Sydney, Sydney, Australia.
⁵ Dept. Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, Spain.
⁶ Nuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UK.
⁷ Applied Psychology and Paediatrics and Child Health, University College Cork, Cork, Ireland.
⁸ Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.
⁹ Pediatric Allergy Unit, Department of Women-Children-Teenagers Pediatrics, University Hospitals of Geneva, Geneva, Switzerland.
¹⁰ Servicio de Alergia, Hospital Clınico San Carlos, UCM, IdISSC, ARADyAL, Madrid, Spain.
¹¹ Center for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine; Department of Pediatrics & Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, USA.
¹² Allergy and Immunology, Department of Pediatrics, New York University School of Medicine, Langone Health, New York, NY, USA.
¹³ Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland.
¹⁴ NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
¹⁵ Clinical and Experimental Sciences and Human Development in Health, Faculty of Medicine, University of Southampton, Southampton, UK.
¹⁶ The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UK.
¹⁷ Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
¹⁸ Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Stanford, CA, USA.
¹⁹ Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USA.
²⁰ Hospital Sírio Libanês, São Paulo, Brazil.
²¹ University Hospital of Montpellier; Sorbonne Universités, Paris, Montpellier, France.
²² Department of Paediatrics, Imperial College, London, United Kingdom.
²³ Department of Pediatrics, Emory University, Atlanta, GA, USA.
²⁴ Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.

Abstract

Background and aims: The term "Food Allergy" refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders.

Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published studies. Studies will be independently screened against pre-defined eligibility criteria and critically appraised by established instruments. Data will be descriptively and, if possible and applicable, quantitatively synthesised.

Ethics and dissemination: This study does not require any specific ethical approval since it is a systematic review. We plan to report results from this systematic review in a peer reviewed journal. These results will be used to inform the development of an international consensus to define severe food allergy. Author's potential conflicts of interest are clearly stated.

Prospero registration number: CRD42020183103.

Keywords: CASP, Critical Appraisal Skills Programme; CBA, controlled before after studies; CCT, controlled clinical trials; CHEERS, Consolidated Health Economic Evaluation Reporting Standards; CI, confidential interval; Classification; Definition; FAIM, food allergy independent measure; FAQL, food allergy quality of life; FARE, Food Allergy Research & Education; Food allergy; GRADE, Grading of Recommendations Assessment, Development and Evaluation; ITS, interrupted time series; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; PROSPERO, Prospective Register of Systematic Reviews; RCT, randomized controlled trials; Severity; WAO, World Allergy Organization.

Publication types

Review