A first approach to an action spectrum for 8-MOP phototumorigenesis in mice

J Invest Dermatol. 1988 Feb;90(2):175-8. doi: 10.1111/1523-1747.ep12462176.

Abstract

Groups of hairless albino mice were treated with 8-MOP and exposed to a fixed daily dose of UVR obtained from one of four different emission spectra. Each spectrum was obtained by filtering a xenon arc source with a different WG filter. The resultant spectra showed differences in their proportions of shorter UVA wavelengths. A decreased proportion of the shorter wave bands systematically increased the time to first tumor. These data suggest that the action spectrum for 8-MOP sensitized phototumorigenesis is similar to that of acute 8-MOP action spectra in mammalian skin, which usually show maximal activity in the 320-335 nm region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • DNA / metabolism
  • Female
  • Methoxsalen / metabolism
  • Methoxsalen / toxicity*
  • Mice
  • Mice, Hairless
  • Neoplasms, Radiation-Induced / etiology*
  • Skin Neoplasms / etiology*
  • Skin Neoplasms / pathology
  • Ultraviolet Rays / adverse effects*

Substances

  • DNA
  • Methoxsalen