Illuminating the immunopathology of SARS-CoV-2

Cytometry B Clin Cytom. 2021 Jan;100(1):33-41. doi: 10.1002/cyto.b.21988. Epub 2021 Jan 4.

Abstract

Over a remarkably short period of time, a great deal of knowledge about severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection has been acquired, through the focused and cooperative effort of the international scientific community. Much has become known about how the immune response is coordinated to fight infection, and how it becomes dysregulated in severe disease. In this review, we take an in-depth look at the many immune features associated with the host response to SARS-CoV2, as well as those that appear to mark severe disease.

Keywords: cytometry; flow cytometry; immune monitoring; immunophenotyping.

Publication types

  • Review

MeSH terms

  • Biomarkers / analysis
  • COVID-19 / diagnostic imaging*
  • COVID-19 / immunology*
  • COVID-19 / pathology
  • COVID-19 / therapy
  • Chemokines / analysis
  • Chemokines / metabolism
  • Cytokines / analysis
  • Cytokines / metabolism
  • Flow Cytometry / methods*
  • Fluorescent Antibody Technique / methods*
  • Fluorescent Antibody Technique / trends
  • Host-Pathogen Interactions / immunology
  • Humans
  • Immunity / physiology
  • Metabolomics / methods
  • Metabolomics / trends
  • Risk Assessment
  • SARS-CoV-2 / immunology*
  • Severity of Illness Index

Substances

  • Biomarkers
  • Chemokines
  • Cytokines