Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical Landscape

Md Shahadat Hossain; Ithmam Hami; Md Sad Salabi Sawrav; Md Fazley Rabbi; Otun Saha; Newaz Mohammed Bahadur; Md Mizanur Rahaman

doi:10.15190/d.2020.18

Drug Repurposing for Prevention and Treatment of COVID-19: A Clinical Landscape

Discoveries (Craiova). 2020 Dec 16;8(4):e121. doi: 10.15190/d.2020.18.

Authors

Md Shahadat Hossain¹, Ithmam Hami¹, Md Sad Salabi Sawrav¹, Md Fazley Rabbi¹, Otun Saha², Newaz Mohammed Bahadur³, Md Mizanur Rahaman²

Affiliations

¹ Department of Biotechnology and Genetic Engineering, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.
² Department of Microbiology, University of Dhaka, Dhaka-1000, Bangladesh.
³ Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali-3814, Bangladesh.

Abstract

SARS-CoV-2, the novel coronavirus strain responsible for the current pandemic of COVID-19, has rendered the entire humanity suffering. Several months have passed since the pandemic has struck. However, the world is still looking for an effective treatment plan to battle the viral infection. The first vaccine just received emergency approval in December 2020 for use in USA and UK. These are excellent news, however, the worldwide distribution of such vaccine, the possibility of virus mutation and the lack of data regarding the long-term effects of such vaccines are a significant concern. In addition, although remdesivir was recently approved by the FDA to be used as a clinical drug against COVID-19, it hasn't stood out yet as a proven form of therapeutics. Such inability to produce a novel therapy has caused enough inconveniences for the affected people worldwide. Repurposing the already available drugs to fight against the virus seems to be a reasonable option amidst such uncertainty. Given the vast collection of potential treatment candidates to be explored against COVID-19, there is a decent chance that a success in this regard will serve the intermediary purpose of clinically treating the infection until a COVID-19 vaccine is widely distributed worldwide and will be able to treat COVID-19 patients that do not adequately respond to vaccines. Such treatments may prove very useful in future coronavirus outbreaks too. Proper research into these repurposing treatments may yield a certain insight into the field of novel treatment production as well. This review study accumulates a relevant set of information about drugs and vaccines against COVID-19, in terms of their repurposing properties and the specific phases of clinical trials they are undergoing across the world. A potential timeline is also suggested to estimate when an effective result can be expected from the ongoing clinical trials for a better anticipation of the drug landscape. This study will hopefully help accelerate investment of resources into development and discovery of drugs and vaccines against the infection.

Keywords: COVID-19; SARS-CoV-2; clinical trial; drug repositioning; phases; therapeutics; vaccine.

Publication types

Review