Age-related alteration in HNE elimination enzymes

Arch Biochem Biophys. 2021 Mar 15:699:108749. doi: 10.1016/j.abb.2020.108749. Epub 2021 Jan 5.

Abstract

4-hydroxynonenal (HNE, 4-hydroxy-2-nonenal) is a primary α,β-unsaturated aldehyde product of lipid peroxidation. The accumulation of HNE increases with aging and the mechanisms are mainly attributable to increased oxidative stress and decreased capacity of HNE elimination. In this review article, we summarize the studies on age-related change of HNE concentration and alteration of HNE metabolizing enzymes (GCL, GST, ALDHs, aldose reductase, and 20S-proteasome), and discuss potential mechanism of age-related decrease in HNE-elimination capacity by focusing on Nrf2 redox signaling.

Keywords: Aging; Bach1; HNE; Lipid peroxidation; Nrf2; Oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aging / metabolism*
  • Aldehydes / metabolism*
  • Animals
  • Humans
  • Oxidative Stress / physiology
  • Oxidoreductases / metabolism
  • Signal Transduction / physiology

Substances

  • Aldehydes
  • Oxidoreductases
  • 4-hydroxy-2-nonenal