Conceptions of the pathophysiology of happy hypoxemia in COVID-19

Sebastiaan Dhont; Eric Derom; Eva Van Braeckel; Pieter Depuydt; Bart N Lambrecht

doi:10.1186/s12931-021-01614-1

Conceptions of the pathophysiology of happy hypoxemia in COVID-19

Respir Res. 2021 Jan 8;22(1):12. doi: 10.1186/s12931-021-01614-1.

Authors

Sebastiaan Dhont¹, Eric Derom^{2

3}, Eva Van Braeckel^{2

3}, Pieter Depuydt^{2

4}, Bart N Lambrecht^{2

3

5}

Affiliations

¹ Department of Internal Medicine and Pediatrics, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium. sebastiaan.dhont@ugent.be.
² Department of Internal Medicine and Pediatrics, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
³ Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
⁴ Department of Intensive Care Medicine, Ghent University Hospital, Ghent, Belgium.
⁵ VIB-UGent Center for Inflammation Research, Ghent, Belgium.

Abstract

In their letter-to-the-editor entitled "Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19", Tobin et al. (Respir Res 21:249, 2020) debated our views on happy hypoxemia in COVID-19 (Respir Res 21:198, 2020). We thank the authors for their interesting comments and alternative viewpoints, and we would like to clarify several important aspects raised.

Keywords: COVID-19; Cytokine storm; Gas exchange; Happy hypoxemia; Respiratory failure.

Publication types

Letter
Comment

MeSH terms

COVID-19* / complications
Humans
Hypoxia*
SARS-CoV-2