Kazachstania slooffiae: An unexpected journey to a human pleural sample

J Mycol Med. 2021 Jun;31(2):101109. doi: 10.1016/j.mycmed.2020.101109. Epub 2020 Dec 30.

Abstract

We report a case of a 50-year-old shepherd hospitalized in intensive care unit for hiatal hernia complicated by an occlusive syndrome. In post-surgery, an acute respiratory distress occurs due to mediastinitis with large pleural effusion. At the laboratory, direct examination of the pleural sample revealed the presence of pseudohyphae. Kazachstania slooffiae was identified by Mass Spectrometry and confirmed by DNA sequencing. This uncommon yeast has never been previously described in human infections. Although its pathogenicity is not well known, K. slooffiae should be considered in the case of critically ill patients.

Keywords: Candida slooffiae; DNA sequencing; Emerging fungal disease; Kazachstania slooffiae; Mass Spectrometry; Zoonoses.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Critical Care
  • Hernia, Hiatal / complications
  • Hernia, Hiatal / diagnostic imaging
  • Hernia, Hiatal / surgery
  • Humans
  • Male
  • Mediastinitis / diagnostic imaging
  • Mediastinitis / etiology
  • Mediastinitis / microbiology
  • Middle Aged
  • Mycoses / diagnostic imaging*
  • Mycoses / drug therapy
  • Mycoses / microbiology
  • Pleural Effusion / microbiology*
  • Saccharomycetales / drug effects
  • Saccharomycetales / genetics*
  • Saccharomycetales / isolation & purification
  • Saccharomycetales / pathogenicity
  • Sequence Analysis, DNA
  • Tomography, X-Ray Computed

Substances

  • Antifungal Agents

Supplementary concepts

  • Kazachstania slooffiae