A Review of Cortical and Subcortical Stimulation Mapping for Language

Neurosurgery. 2021 Aug 16;89(3):331-342. doi: 10.1093/neuros/nyaa436.

Abstract

Since the early descriptions of language function based on observations of patients with language deficits by Broca and Wernicke, neurosurgeons have been focused on characterizing the anatomic regions necessary for language perception and production, and preserving these structures during surgery to minimize patient deficits post operatively. In this supplementary issue on awake intraoperative mapping, we review language processing across multiple domains, highlighting key advances in direct electrical stimulation of different cortical and subcortical regions involved in naming, repetition, reading, writing, and syntax. We then discuss different intraoperative tasks for assessing the function of a given area and avoiding injury to critical, eloquent regions.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Brain Mapping
  • Brain Neoplasms*
  • Electric Stimulation
  • Humans
  • Language*
  • Neurosurgeons
  • Wakefulness