[Research progress on non-steroidal anti-inflammatory drug related bowel disease and gut microbiota]

Zhonghua Nei Ke Za Zhi. 2021 Feb 1;60(2):175-178. doi: 10.3760/cma.j.cn112138-20200312-00230.
[Article in Chinese]

Abstract

非甾体类抗炎药临床应用广泛,其不良反应也愈加凸显,特别是非甾体类抗炎药相关肠病,尚无明确的防治策略。目前研究认为肠道菌群在其发病机制中起关键作用,以革兰阴性菌异常增殖为特征的肠道菌群紊乱诱发异常肠道黏膜免疫反应,造成炎症及肠道损伤。益生菌制剂和利福昔明能显著缓解非甾体类抗炎药造成的肠道损伤。现就非甾体类抗炎药相关肠病与肠道菌群关系的研究进展做一综述,为临床诊治和后续研究提供参考。.

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Gastrointestinal Microbiome*
  • Humans
  • Inflammatory Bowel Diseases* / drug therapy
  • Pharmaceutical Preparations*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Pharmaceutical Preparations