Early Detection of Aortic Degeneration in a Mouse Model of Sporadic Aortic Aneurysm and Dissection Using Nanoparticle Contrast-Enhanced Computed Tomography

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1534-1548. doi: 10.1161/ATVBAHA.120.315210. Epub 2021 Feb 4.

Ketan B Ghaghada^{1

2

3}, Pingping Ren⁴, Laxman Devkota^{1

5}, Zbigniew Starosolski^{1

2}, Chen Zhang⁴, Deborah Vela⁶, Igor V Stupin¹, Eric A Tanifum^{1

2}, Ananth V Annapragada^{1

2

3}, Ying H Shen^{3

4

7}, Scott A LeMaire^{3

4

7}

¹ Edward B. Singleton Department of Radiology, Texas Children's Hospital, Houston (K.B.G., L.D., Z.S., I.V.S., E.A.T., A.V.A.).
² Department of Radiology (K.B.G., Z.S., E.A.T., A.V.A.), Baylor College of Medicine, Houston, TX.
³ Cardiovascular Research Institute (K.B.G., A.V.A., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
⁴ Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery (P.R., C.Z., Y.H.S., S.A.L.), Baylor College of Medicine, Houston, TX.
⁵ Department of Pediatrics, Section of Hematology-Oncology (L.D.), Baylor College of Medicine, Houston, TX.
⁶ Department of Cardiovascular Pathology Research (D.V.), Texas Heart Institute, Houston.
⁷ Department of Cardiovascular Surgery (Y.H.S., S.A.L.), Texas Heart Institute, Houston.

Abstract

[Figure: see text].

Keywords: aneurysm, dissection; angiotensin II; aortic aneurysm; contrast media; nanoparticles.