A dihydrofolate reductase 2 (DHFR2) variant is associated with risk of neural tube defects in an Irish cohort but not in a United Kingdom cohort

Am J Med Genet A. 2021 Apr;185(4):1307-1311. doi: 10.1002/ajmg.a.62090. Epub 2021 Feb 5.

Authors

Faith Pangilinan¹, Emma K Finlay², Anne M Molloy³, Hattice O Abaan¹, Barry Shane⁴, James L Mills⁵, Lawrence C Brody¹, Anne Parle-McDermott²

Affiliations

¹ Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, Maryland, USA.
² School of Biotechnology, Dublin City University, Dublin, Ireland.
³ Department of Clinical Medicine, School of Medicine, Trinity College, Dublin, Ireland.
⁴ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California, USA.
⁵ Division of Intramural Population Health Research, Eunice Kennedy Shriver, National Institute for Child Health and Human Development, Bethesda, Maryland, USA.

PMID: 33544972
DOI: 10.1002/ajmg.a.62090

No abstract available

Publication types

Letter
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Ethnicity / genetics
Female
Genetic Association Studies*
Genetic Predisposition to Disease*
Humans
Ireland / epidemiology
Male
Neural Tube Defects / epidemiology
Neural Tube Defects / genetics*
Neural Tube Defects / pathology
Polymorphism, Single Nucleotide / genetics
Tetrahydrofolate Dehydrogenase / genetics*
United Kingdom / epidemiology

Substances

dihydrofolate reductase type II
Tetrahydrofolate Dehydrogenase

Grants and funding

Intramural Research Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development