Effectiveness of intervention program on the change of glycaemic control in diabetes with depression patients: A meta-analysis of randomized controlled studies

Xiaobing Lu; Dongying Yang; Jiaquan Liang; Guojun Xie; Xuesong Li; Caixia Xu; Hairong Liao; Hui Zhou; Zhenyu Xu; Chan Ye; Haixia Chen; Meihong Liang; Qi Shen; Ting Sun; Yutong Hu; Weizhi Zhang; Yuping Ning

doi:10.1016/j.pcd.2021.01.006

Effectiveness of intervention program on the change of glycaemic control in diabetes with depression patients: A meta-analysis of randomized controlled studies

Prim Care Diabetes. 2021 Jun;15(3):428-434. doi: 10.1016/j.pcd.2021.01.006. Epub 2021 Feb 5.

Authors

Xiaobing Lu¹, Dongying Yang², Jiaquan Liang³, Guojun Xie³, Xuesong Li³, Caixia Xu³, Hairong Liao⁴, Hui Zhou⁴, Zhenyu Xu⁵, Chan Ye⁵, Haixia Chen⁶, Meihong Liang⁷, Qi Shen⁵, Ting Sun⁵, Yutong Hu⁵, Weizhi Zhang⁵, Yuping Ning⁸

Affiliations

¹ Department of Psychiatric, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
² Department of Psychological Behavior, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
³ Department of Psychiatric, The Third People's Hospital of Foshan, Foshan, China.
⁴ Department of Psychiatric, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Department of Psychiatric, The Third People's Hospital of Foshan, Foshan, China.
⁵ Department of Psychiatric, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
⁶ Department of Psychiatric, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Department of Psychiatric, Zhongshan Third People's Hospital, Zhongshan, China.
⁷ Department of Psychiatry, Guangzhou Medical University, Foshan Third People's Hospital, Foshan, China.
⁸ Department of Psychiatric, Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. Electronic address: 13688876346@139.com.

PMID: 33551333
DOI: 10.1016/j.pcd.2021.01.006

Abstract

Aim: The glycaemic control of diabetes with depression was inconsistent from randomized controlled studies. This meta-analysis aimed to explore the effectiveness of intervention methods in diabetes with depression.

Methods: This study systematically searched electronic databases (PubMed, EBSCO, Elsevier, Springer, Wiley, and Cochrane) for studies published up to August 17, 2020. Standardized mean difference (SMD) and 95%CI were used to evaluate the effectiveness of interventions on HbA1c. Heterogeneity was estimated using the I² statistic. Begg's test was used to assess the possible publication bias among studies.

Results: Twelve studies of 2444 cases were included in this study. The overall SMD is -0.22 and 95%CI -0.33 to -0.10 in 0-6 months of intervention group. The I² and P were 18.4% and 0.26. There are no publication bias tested (z = 0.37, P = 0.72).

Conclusion: Cognitive behavioral therapy and mindful self-compassion might be effective method to improve glycaemic control of diabetes with depression in 0-6 months.

Keywords: Depression; Diabetes; Glycaemic control; HbA1c; Meta-analysis.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cognitive Behavioral Therapy*
Depression / diagnosis
Depression / prevention & control
Diabetes Mellitus*
Glycemic Control
Humans