P53 orchestrates a complex symphony of cellular processes during oncosuppression

Liz J Valente; Laura D Attardi

doi:10.1080/23723556.2020.1852066

P53 orchestrates a complex symphony of cellular processes during oncosuppression

Mol Cell Oncol. 2021 Jan 11;8(1):1852066. doi: 10.1080/23723556.2020.1852066. eCollection 2021.

Authors

Liz J Valente¹, Laura D Attardi^{1

2

3}

Affiliations

¹ Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, USA.
² Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
³ Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Abstract

We recently showed that the p53 tumor suppressor simultaneously governs numerous cellular processes in one model of transformation suppression. These findings suggest that p53-mediated tumor suppression relies on coordinated modulation of diverse cellular functions in a particular context, helping to explain why loss of the TP53 (tumor protein p53) gene is so prevalent in human cancers.

Keywords: P53; cancer; cell biology; transformation; tumor suppression.

Grants and funding

R35 CA197591/CA/NCI NIH HHS/United States