Metformin Is Associated With a Lower Risk of Atrial Fibrillation and Ventricular Arrhythmias Compared With Sulfonylureas: An Observational Study

Circ Arrhythm Electrophysiol. 2021 Mar;14(3):e009115. doi: 10.1161/CIRCEP.120.009115. Epub 2021 Feb 7.

Authors

Anna Ostropolets¹, Pierre A Elias², Michael V Reyes², Elain Y Wan², Utpal B Pajvani², George Hripcsak^{1

2}, John P Morrow²

Affiliations

¹ Department of Biomedical Informatics (A.O., G.H.), College of Physicians and Surgeons of Columbia University, NY.
² Department of Medicine (P.A.E., M.V.R., E.Y.W., U.B.P., G.H., J.P.M.), College of Physicians and Surgeons of Columbia University, NY.

Abstract

[Figure: see text].

Keywords: atrial fibrillation; metformin; propensity score; thiazolidinediones; ventricular fibrillation.

Publication types

Comparative Study
Observational Study
Research Support, N.I.H., Extramural

MeSH terms

Administration, Oral
Atrial Fibrillation / diagnosis
Atrial Fibrillation / etiology
Atrial Fibrillation / physiopathology
Atrial Fibrillation / prevention & control*
Databases, Factual
Diabetes Mellitus, Type 2 / complications
Diabetes Mellitus, Type 2 / diagnosis
Diabetes Mellitus, Type 2 / drug therapy*
Drug Therapy, Combination
Humans
Hypoglycemic Agents / administration & dosage*
Metformin / administration & dosage*
Retrospective Studies
Risk Assessment
Risk Factors
Sulfonylurea Compounds / administration & dosage*
Tachycardia, Ventricular / diagnosis
Tachycardia, Ventricular / etiology
Tachycardia, Ventricular / physiopathology
Tachycardia, Ventricular / prevention & control*
Time Factors
Treatment Outcome
Ventricular Fibrillation / diagnosis
Ventricular Fibrillation / etiology
Ventricular Fibrillation / physiopathology
Ventricular Fibrillation / prevention & control*

Substances

Hypoglycemic Agents
Sulfonylurea Compounds
Metformin

Grants and funding