Anticytomegalovirus CD4⁺ T Cells Are Associated With Subclinical Atherosclerosis in Persons With HIV

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1459-1473. doi: 10.1161/ATVBAHA.120.315786. Epub 2021 Feb 11.

Authors

Celestine N Wanjalla^{1

2}, Mona Mashayekhi³, Samuel Bailin¹, Curtis L Gabriel^{2

4}, Leslie M Meenderink^{1

5

6}, Tecla Temu⁷, Daniella T Fuller⁸, Liang Guo⁸, Kenji Kawai⁸, Renu Virmani⁸, Cathy Jenkins⁹, Chike O Abana¹⁰, Christian M Warren^{1

2}, Rama Gangula¹, Rita Smith¹, Meena S Madhur¹¹, Aloke V Finn, Alexander H Gelbard¹², Yan Ru Su¹³, Matthew J Tyska, Spyros A Kalams^{1

2

12

14}, David G Harrison¹¹, Simon A Mallal^{1

2}, Tarek S Absi¹⁵, Joshua A Beckman¹³, John R Koethe^{1

2

6}

Affiliations

¹ Division of Infectious Diseases (C.N.W., S.B., L.M.M., C.M.W., R.G., R.S., S.A.K., S.A.M., J.R.K.), Vanderbilt University Medical Center, Nashville.
² Tennessee Center for AIDS Research (C.N.W., C.L.G., C.M.W., R.S., S.A.K., S.A.M., J.R.K.), Vanderbilt University Medical Center, Nashville.
³ Division of Diabetes, Endocrinology and Metabolism (M.M.), Vanderbilt University Medical Center, Nashville.
⁴ Division of Gastroenterology (C.L.G., ), Vanderbilt University Medical Center, Nashville.
⁵ Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN (L.M.M.).
⁶ Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN (L.M.M., J.R.K.).
⁷ Department of Global Health, University of Washington, Seattle (T.T.).
⁸ CVPath Institute, Gaithersburg, MD (D.T.F., L.G., K.K., R.V.).
⁹ Department of Biostatistics (C.J.), Vanderbilt University Medical Center, Nashville.
¹⁰ Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston (C.O.A.).
¹¹ Division of Clinical Pharmacology (M.S.M., D.G.H.), Vanderbilt University Medical Center, Nashville.
¹² Department of Otolaryngology (A.H.G., S.A.M.), Vanderbilt University Medical Center, Nashville.
¹³ Division of Cardiovascular Medicine (Y.R.S., J.A.B.), Vanderbilt University Medical Center, Nashville.
¹⁴ Vanderbilt Technologies for Advanced Genomics (VANTAGE) (S.A.M.), Vanderbilt University Medical Center, Nashville.
¹⁵ Department of Cardiac Surgery (T.S.A.), Vanderbilt University Medical Center, Nashville.

Abstract

[Figure: see text].

Keywords: HIV; atherosclerosis; cardiovascular diseases; cytomegalovirus; inflammation.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adult
Asymptomatic Diseases
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes / immunology*
CD4-Positive T-Lymphocytes / virology
Carotid Artery Diseases / diagnostic imaging
Carotid Artery Diseases / immunology*
Carotid Artery Diseases / virology
Case-Control Studies
Coinfection*
Coronary Artery Disease / diagnostic imaging
Coronary Artery Disease / immunology*
Coronary Artery Disease / virology
Cross-Sectional Studies
Cytomegalovirus / immunology*
Cytomegalovirus Infections / diagnosis
Cytomegalovirus Infections / immunology*
Cytomegalovirus Infections / virology
Epitopes
Female
HIV Infections / diagnosis
HIV Infections / immunology*
HIV Infections / virology
Heart Disease Risk Factors
Humans
Male
Middle Aged
Plaque, Atherosclerotic
Risk Assessment
Vasodilation
Viral Envelope Proteins / immunology*

Substances

Epitopes
Viral Envelope Proteins
glycoprotein B, Simplexvirus

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