Exploration of Sepsis-Associated Coagulopathy Severity and Pediatric Septic Shock Outcomes

Jeremy M Loberger; Inmaculada B Aban; Priya Prabhakaran

doi:10.1055/s-0040-1713436

Exploration of Sepsis-Associated Coagulopathy Severity and Pediatric Septic Shock Outcomes

J Pediatr Intensive Care. 2021 Mar;10(1):38-44. doi: 10.1055/s-0040-1713436. Epub 2020 Jun 26.

Authors

Jeremy M Loberger¹, Inmaculada B Aban², Priya Prabhakaran¹

Affiliations

¹ Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, United States.
² Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States.

Abstract

The objective of this study was to explore correlations between sepsis-associated coagulopathy (SAC) in pediatric septic shock and clinical outcomes. This was a retrospective cohort study of all children admitted to a single, academic pediatric intensive care unit with septic shock over 6 years. The prevalence of SAC was 93.5% with 61% being severe. Those with severe SAC were more likely to have a positive blood culture and have longer median duration of ventilation. All observed mortalities occurred in the severe SAC and indeterminate SAC groups. SAC is highly prevalent in pediatric septic shock and may predict important outcomes.

Keywords: PICU; disseminated intravascular coagulation; septic shock.

Grants and funding

Funding None.