Pathological Angiogenesis Requires Syndecan-4 for Efficient VEGFA-Induced VE-Cadherin Internalization

Arterioscler Thromb Vasc Biol. 2021 Apr;41(4):1374-1389. doi: 10.1161/ATVBAHA.121.315941. Epub 2021 Feb 18.

Authors

Giulia De Rossi^{1

2}, Maria Vähätupa^{3

4}, Enrico Cristante⁵, Samantha Arokiasamy¹, Sidath E Liyanage⁵, Ulrike May^{3

4}, Laura Pellinen^{3

4}, Hannele Uusitalo-Järvinen^{3

4}, James W Bainbridge⁵, Tero A H Järvinen^{3

4}, James R Whiteford¹

Affiliations

¹ William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom (G.D.R., S.A., J.R.W.).
² Department of Cell Biology (G.D.R.), UCL Institute of Ophthalmology, London, United Kingdom.
³ Faculty of Medicine and Health Technology, Tampere University, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
⁴ Departments of Orthopedics and Traumatology and Tampere Eye Centre, Tampere University Hospital, Finland (M.V., U.M., L.P., H.U.-J., T.A.H.J.).
⁵ Genetics Department (E.C., S.E.L., J.W.B.), UCL Institute of Ophthalmology, London, United Kingdom.

Abstract

[Figure: see text].

Keywords: cadherins; diabetic retinopathy; permeability; syndecans; vascular endothelial growth factor A.

Publication types

Research Support, Non-U.S. Gov't
Video-Audio Media

MeSH terms

Animals
Antigens, CD / metabolism*
Cadherins / metabolism*
Capillary Permeability
Choroidal Neovascularization / genetics
Choroidal Neovascularization / metabolism*
Choroidal Neovascularization / pathology
Disease Models, Animal
Endothelial Cells / drug effects
Endothelial Cells / metabolism
Female
Humans
Macular Degeneration / genetics
Macular Degeneration / metabolism*
Macular Degeneration / pathology
Male
Melanoma, Experimental / genetics
Melanoma, Experimental / metabolism*
Melanoma, Experimental / pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neovascularization, Pathologic*
Neovascularization, Physiologic / drug effects*
Retinal Neovascularization / genetics
Retinal Neovascularization / metabolism*
Retinal Neovascularization / pathology
Retinal Vessels / drug effects*
Retinal Vessels / metabolism*
Retinal Vessels / pathology*
Signal Transduction
Skin Neoplasms / genetics
Skin Neoplasms / metabolism*
Skin Neoplasms / pathology
Syndecan-4 / genetics
Syndecan-4 / metabolism*
Vascular Endothelial Growth Factor A / pharmacology*
Vascular Endothelial Growth Factor Receptor-2 / agonists
Vascular Endothelial Growth Factor Receptor-2 / metabolism

Substances

Antigens, CD
Cadherins
Sdc4 protein, mouse
Syndecan-4
Vascular Endothelial Growth Factor A
cadherin 5
Kdr protein, mouse
Vascular Endothelial Growth Factor Receptor-2

Grants and funding