Potential for production of medical radionuclides with on-line isotope separation at the ISAC facility at TRIUMF and particular discussion of the examples of 165Er and 155Tb

Abstract

Production of medical radionuclides with ISOL facilities is a unique production method that may provide access to preclinical quantities of some rare and potent radionuclides for nuclear medicine. Particularly attention over the past years was focused on several promising candidates for Targeted Radionuclides Therapy (TRT). With this review, we provide some perspectives of using the TRIUMF ISOL facility (ISAC) to produce medical radionuclides for TRT application and highlight our current effort to collect of ¹⁶⁵Er and ¹⁵⁵Tb for Auger Therapy and SPECT imaging, respectively.

Keywords: (155)Tb; (165)Er; Auger electrons; ISOL facility; Production of medical isotopes; Targeted radionuclide therapy.