Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD

Abstract

Recently, three groups, Girardi et al., Kory et al., and Luongo et al., independently identified solute carrier (SLC) 25A51 as the long-sought, major mitochondrial NAD⁺ transporter in mammalian cells. These studies not only deorphan an uncharacterized transporter of the SLC25A family, but also shed light on other aspects of NAD⁺ biology.

Keywords: NAD; SLC25A family; mitochondrial transporter; redox; respiration.