A not-so-simple twist of fate

Alexandra F Long; Tim Stearns

doi:10.1016/j.devcel.2021.02.003

A not-so-simple twist of fate

Dev Cell. 2021 Feb 22;56(4):402-404. doi: 10.1016/j.devcel.2021.02.003.

Authors

Alexandra F Long¹, Tim Stearns²

Affiliations

¹ Department of Biology, Stanford University, Stanford, CA 94305, USA.
² Department of Biology, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: stearns@stanford.edu.

PMID: 33621489
DOI: 10.1016/j.devcel.2021.02.003

Abstract

Multiciliated cells are considered terminally differentiated, yet tissues bearing them are remodeled during development and after injury. In this issue of Developmental Cell, Tasca et al. (2021) show that multiciliated epithelial cells are lost via two different Notch-dependent processes, apoptosis and transdifferentiation, during developmental remodeling of the Xenopus epidermis.

Publication types

Comment

MeSH terms

Animals
Cell Differentiation
Cell Transdifferentiation
Epidermal Cells*
Epithelial Cells*
Xenopus laevis

Grants and funding

R35 GM130286/GM/NIGMS NIH HHS/United States