Neonatal lupus erythematosus presenting as orolabial ulcerations: Two cases and a review of the literature

Pediatr Dermatol. 2021 May;38(3):643-646. doi: 10.1111/pde.14555. Epub 2021 Mar 5.

Abstract

We report two unrelated infants who presented with orolabial ulcerations as a presenting manifestation of neonatal lupus erythematosus (NLE). Subsequent positive anti-SSA/SSB titers confirmed the diagnosis. In both infants, the ulcerations were painless and spontaneously resolved. NLE should be included in the differential diagnosis of orolabial ulcerations in the newborn, especially since mothers of affected infants may be asymptomatic.

Keywords: cutaneous; lupus; neonatal lupus; orolabial; ulceration.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Antinuclear
  • Diagnosis, Differential
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Lupus Erythematosus, Cutaneous* / diagnosis
  • Lupus Erythematosus, Cutaneous* / drug therapy
  • Lupus Erythematosus, Systemic* / complications
  • Lupus Erythematosus, Systemic* / congenital
  • Lupus Erythematosus, Systemic* / diagnosis
  • Lupus Erythematosus, Systemic* / drug therapy
  • Mothers

Substances

  • Antibodies, Antinuclear

Supplementary concepts

  • Neonatal Systemic lupus erythematosus