Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury

Demin Liu; Songling Tang; Lu Gan; Wei Cui

doi:10.1155/2021/5579327

Renal-Protective Effects and Potential Mechanisms of Traditional Chinese Medicine after Ischemia-Reperfusion Injury

Evid Based Complement Alternat Med. 2021 Feb 19:2021:5579327. doi: 10.1155/2021/5579327. eCollection 2021.

Authors

Demin Liu¹, Songling Tang², Lu Gan², Wei Cui¹

Affiliations

¹ Cardiology Department, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
² Research Laboratory of Emergency Medicine, Department of Emergency Medicine, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

Renal ischemia-reperfusion (I/R) injury mainly causes acute kidney injury (AKI) after renal transplantation, trauma, sepsis, and hypovolemic shock. Patients with renal I/R injury are frequently associated with a poor prognosis. Traditional Chinese medicine (TCM) has been used for the prevention and treatment of various diseases in China and other Asian countries for centuries. Many studies have shown the protective effect of TCM on renal I/R injury, due to its diverse bioactive components. The potential mechanisms of TCMs on renal I/R injury include anti-inflammation, antioxidative effect, anti-cell death, downregulation of adhesion molecule expression, regulation of energy metabolism by restoring Na⁺-K⁺-ATPase activity, and mitochondrial fission. This review summarizes the major developments in the effects and underlying mechanisms of TCMs on the renal I/R injury.

Publication types

Review