Metabolic regulation of tissue-resident memory CD8+ T cells

Abstract

Intracellular metabolic adaptations help define the function and homeostasis of memory CD8⁺ T cells. These cells, which promote protection against infections or cancer, undergo consecutive metabolic shifts, ultimately relying on mitochondrial-related pathways. Past CD8⁺ T cell metabolism studies focused on circulating memory cells, which are exclusive to secondary lymphoid organs or recirculate between lymphoid and non-lymphoid organs. Yet, now there is unequivocal evidence that memory CD8⁺ T cells reside in many non-lymphoid organs and mediate protective immunity in barrier tissues. The metabolic adaptations occurring in forming and established tissue-resident memory CD8⁺ T cells are currently subject of intense research. In this review, we discuss the latest breakthroughs on the transcriptional and protein control of tissue-resident memory CD8⁺ T cell metabolism.

Keywords: Bhlhe40; Memory CD8(+) T cells; Memory precursor; Mitochondria; P2RX7; T(RM) cells.