Retropharyngeal chordoma extending to the spinal cord, mimicking a neurogenic tumor: a case report and literature review

J Int Med Res. 2021 Mar;49(3):300060521999566. doi: 10.1177/0300060521999566.

Abstract

Chordomas are rare, locally aggressive bone malignancies with poor prognoses. However, those with minimal or no bone involvement are more easily resectable because of their well-delineated margins and thus have better prognoses. Such extraosseous chordomas of the spine are localized both intradurally and extradurally. Only a few case reports have focused on extraosseous, extradural spinal chordomas. Radiologically, this type of chordoma has a dumbbell shape; however, dumbbell-shaped spinal tumors are traditionally thought to be neurogenic tumors (i.e., schwannomas or neurofibromas). We herein report a unique case involving a woman with a dumbbell-shaped extraosseous chordoma protruding predominantly into the retropharyngeal space. A 44-year-old woman presented for evaluation of a left submandibular mass. A T2-hyperintense, gadolinium-enhancing mass was found in her cervical spinal canal, protruding through the C2/3 neural foramen into the retropharyngeal space with minimal vertebral involvement. The initial diagnosis was a neurogenic tumor, most likely a schwannoma. After subtotal removal, the pathologic diagnosis was a chordoma. Because chordomas and schwannomas have significantly different prognoses, caution is warranted when a dumbbell-shaped tumor is identified in the spine with minimal or no vertebral deterioration on radiology. This report also provides the first thorough review of extraosseous dumbbell-shaped intraspinal-extraspinal chordomas.

Keywords: Chordoma; case report; dumbbell; extraosseous; neurogenic tumor; retropharyngeal space.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Chordoma* / diagnostic imaging
  • Chordoma* / surgery
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Neurilemmoma*
  • Spinal Cord Neoplasms*
  • Spinal Neoplasms* / diagnostic imaging
  • Spinal Neoplasms* / surgery