HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia

Blood. 2021 Jun 24;137(25):3576-3580. doi: 10.1182/blood.2020010586.

Authors

Kohei Hosokawa¹, Hiroki Mizumaki¹, Takeshi Yoroidaka¹, Hiroyuki Maruyama¹, Tatsuya Imi¹, Noriaki Tsuji¹, Ryota Urushihara¹, Mikoto Tanabe¹, Yoshitaka Zaimoku¹, Mai Anh Thi Nguyen¹, Dung Cao Tran¹, Ken Ishiyama¹, Hirohito Yamazaki², Takamasa Katagiri³, Hiroyuki Takamatsu¹, Kazuyoshi Hosomichi⁴, Atsushi Tajima⁴, Fumihiro Azuma⁵, Seishi Ogawa⁶, Shinji Nakao¹

Affiliations

¹ Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
² Division of Transfusion Medicine, Kanazawa University Hospital, Kanazawa, Japan.
³ Department of Clinical Laboratory Science, Graduate Course of Medical Science and Technology and.
⁴ Department of Bioinformatics and Genomics, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan.
⁵ HLA Laboratory, Japanese Red Cross Kanto-Koshinetsu Block Blood Center, Tokyo, Japan; and.
⁶ Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Japan.

PMID: 33754630
DOI: 10.1182/blood.2020010586

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Clonal Evolution / genetics
Clonal Evolution / immunology*
Female
HLA-A Antigens* / genetics
HLA-A Antigens* / immunology
Humans
Leukemia, Myeloid, Acute* / genetics
Leukemia, Myeloid, Acute* / immunology
Leukocytes / immunology*
Male
Middle Aged
Myelodysplastic Syndromes* / genetics
Myelodysplastic Syndromes* / immunology
Retrospective Studies

Substances

HLA-A Antigens