NINJ1, rupturing swollen membranes for cataclysmic cell lysis

Yupeng Wang; Feng Shao

doi:10.1016/j.molcel.2021.03.005

NINJ1, rupturing swollen membranes for cataclysmic cell lysis

Mol Cell. 2021 Apr 1;81(7):1370-1371. doi: 10.1016/j.molcel.2021.03.005.

Authors

Yupeng Wang¹, Feng Shao²

Affiliations

¹ National Institute of Biological Sciences, Beijing, P.R. China.
² National Institute of Biological Sciences, Beijing, P.R. China. Electronic address: shaofeng@nibs.ac.cn.

PMID: 33798414
DOI: 10.1016/j.molcel.2021.03.005

Abstract

Using a forward-genetic screening of macrophages from randomly mutagenized mice, Kayagaki et al. (2021) identify NINJ1 that mediates plasma membrane rupture following various types of programmed cell death, an event previously thought to be passive.

Publication types

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MeSH terms

Animals
Cell Adhesion Molecules, Neuronal*
Cell Membrane
Endothelial Cells
Macrophages
Mice
Nerve Growth Factors*

Substances

Cell Adhesion Molecules, Neuronal
Nerve Growth Factors
Ninj1 protein, mouse