Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study

Matthew D Seftel; Pintip Chitphakdithai; John P Miller; Hati Kobusingye; Brent R Logan; Michael Linenberger; Andrew S Artz; Ann E Haight; David A Jacobsohn; Mark R Litzow; Margarida Magalhaes-Silverman; George B Selby; Madhuri Vusirikala; Mary M Horowitz; Galen E Switzer; Dennis L Confer; Bronwen E Shaw; Michael A Pulsipher

doi:10.1016/j.jtct.2021.01.009

Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study

Transplant Cell Ther. 2021 Apr;27(4):352.e1-352.e5. doi: 10.1016/j.jtct.2021.01.009. Epub 2021 Jan 15.

Authors

Matthew D Seftel¹, Pintip Chitphakdithai², John P Miller³, Hati Kobusingye², Brent R Logan⁴, Michael Linenberger⁵, Andrew S Artz⁶, Ann E Haight⁷, David A Jacobsohn⁸, Mark R Litzow⁹, Margarida Magalhaes-Silverman¹⁰, George B Selby¹¹, Madhuri Vusirikala¹², Mary M Horowitz⁴, Galen E Switzer¹³, Dennis L Confer¹⁴, Bronwen E Shaw¹⁵, Michael A Pulsipher¹⁶

Affiliations

¹ University of British Columbia, Vancouver, British Columbia, Canada.
² Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota.
³ National Marrow Donor Program/Be The Match, Minneapolis, Minnesota.
⁴ Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
⁵ Fred Hutchinson Cancer Research Center, Seattle, Washington.
⁶ University of Chicago Hospitals, Chicago, Illinois.
⁷ Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia.
⁸ Children's National Medical Center, Washington, District of Columbia.
⁹ Mayo Clinic Rochester, Rochester, Minnesota.
¹⁰ University of Iowa Hospitals & Clinics, Iowa City, Iowa.
¹¹ HCA Health Services of Oklahoma, Inc., University of Oklahoma, Oklahoma City, Oklahoma.
¹² University of Texas Southwestern Medical Center, Dallas, Texas.
¹³ University of Pittsburgh, Pittsburgh, Pennsylvania.
¹⁴ Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, Minneapolis, Minnesota; National Marrow Donor Program/Be The Match, Minneapolis, Minnesota.
¹⁵ Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address: beshaw@mcw.edu.
¹⁶ Children's Hospital Los Angeles Cancer and Blood Disease Institute, USC Keck School of Medicine, Los Angeles, California.

Abstract

The incidence and risk factors for severe adverse events (SAEs) in related donors (RD) of hematopoietic cell transplants is unknown. The Related Donor Safe study is a prospective observational cohort of 1680 RDs and represents an opportunity to examine characteristics of SAEs in RDs. In this cohort, we found that SAEs were reported in a total 12 (0.71%) RDs. Of these, 5 SAEs occurred in bone marrow donors (5/404, 1.24%), and 7 (7/1276, 0.55%) were in donors of peripheral blood stem cells. All of the SAEs were considered to be related (definite, probable, or possible) to the donation process. There were no donor fatalities. Of the 12 RDs who experienced an SAE, 10 were either overweight or obese. Five of the 12 RDs had predonation medical conditions that would have resulted in either possible or definite ineligibility for donation were they being assessed as unrelated donors. These SAE data will be useful in the counseling of prospective RDs before planned donation and may be helpful in identifying donors who should be considered medically unsuitable for donation.

Keywords: Adverse events; Allogeneic hematopoietic cell transplantation; Related donors.

Publication types

Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cohort Studies
Humans
Peripheral Blood Stem Cells*
Prospective Studies
Risk Factors
Unrelated Donors

Abstract

Publication types

MeSH terms

Grants and funding