Multimodal brain predictors of current weight and weight gain in children enrolled in the ABCD study ®

Abstract

Multimodal neuroimaging assessments were utilized to identify generalizable brain correlates of current body mass index (BMI) and predictors of pathological weight gain (i.e., beyond normative development) one year later. Multimodal data from children enrolled in the Adolescent Brain Cognitive Development Study® at 9-to-10-years-old, consisted of structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), resting state (rs), and three task-based functional (f) MRI scans assessing reward processing, inhibitory control, and working memory. Cross-validated elastic-net regression revealed widespread structural associations with BMI (e.g., cortical thickness, surface area, subcortical volume, and DTI), which explained 35% of the variance in the training set and generalized well to the test set (R² = 0.27). Widespread rsfMRI inter- and intra-network correlations were related to BMI (R²_train = 0.21; R²_test = 0.14), as were regional activations on the working memory task (R²_train = 0.20; (R²_test = 0.16). However, reward and inhibitory control tasks were unrelated to BMI. Further, pathological weight gain was predicted by structural features (Area Under the Curve (AUC)_train = 0.83; AUC_test = 0.83, p < 0.001), but not by fMRI nor rsfMRI. These results establish generalizable brain correlates of current weight and future pathological weight gain. These results also suggest that sMRI may have particular value for identifying children at risk for pathological weight gain.

Keywords: Childhood obesity; Inhibitory control; Machine-learning; Reward; Weight gain; Weight stability; fMRI.