Novel Treatment of Infant With COVID-19 With the Sialidase Fusion Protein, DAS181

Pediatr Infect Dis J. 2021 Jun 1;40(6):e234-e235. doi: 10.1097/INF.0000000000003122.

Abstract

We describe the successful treatment of a 10-month-old female with respiratory distress secondary to Coronavirus disease 2019 (COVID-19) with the nebulized investigational drug, DAS181. Therapy was well tolerated, and the patient had minimal side effects. The patient's respiratory distress and positive viral polymerase chain reaction rapidly resolved after initiation of therapy.

Publication types

  • Case Reports

MeSH terms

  • Antiviral Agents / therapeutic use*
  • COVID-19 / diagnostic imaging
  • COVID-19 / physiopathology
  • COVID-19 Drug Treatment*
  • Female
  • Humans
  • Infant
  • Neuraminidase / therapeutic use*
  • Recombinant Fusion Proteins / therapeutic use*
  • SARS-CoV-2 / isolation & purification

Substances

  • Antiviral Agents
  • Recombinant Fusion Proteins
  • oplunofusp
  • Neuraminidase