Abstract
As part of the CASP competition, the protein structure prediction algorithm AlphaFold2 generated multiple models of the proton/drug antiporter LmrP. Previous distance restraints from double electron-electron resonance spectroscopy, a technique which reports distance distributions between spin labels attached to proteins, suggest that one of the lower-ranked models may have captured a conformation that has so far eluded experimental structure determination.
© 2021 Wiley Periodicals LLC.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Algorithms*
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Bacterial Proteins / chemistry*
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Bacterial Proteins / genetics
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Bacterial Proteins / metabolism
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Binding Sites
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Biological Transport
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Cell Membrane / chemistry*
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Cell Membrane / metabolism
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Gene Expression
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Lactococcus lactis / chemistry*
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Lactococcus lactis / genetics
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Lactococcus lactis / metabolism
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Membrane Transport Proteins / chemistry*
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Membrane Transport Proteins / genetics
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Membrane Transport Proteins / metabolism
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Models, Molecular
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Protein Binding
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Protein Conformation, alpha-Helical
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Protein Interaction Domains and Motifs
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Protons
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Software*
Substances
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Bacterial Proteins
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LmrP protein, Lactococcus lactis
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Membrane Transport Proteins
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Protons