C-reactive protein, chemerin, fetuin-A and osteopontin as predictors of cardiovascular risks in persons with psoriasis vulgaris

Physiol Res. 2021 Jul 12;70(3):383-391. doi: 10.33549/physiolres.934654. Epub 2021 May 12.

Abstract

The study aimed to contribute to understanding the role of CRP, chemerin, fetuin-A and osteopontin and to assess their suitability as biomarkers of early stages of cardiovascular diseases in psoriasis vulgaris. Serum levels measured in 28 patients and 22 controls. Patients: increased levels of CRP (p<0.001), chemerin (p<0.05), osteopontin (p<0.05) and decreased levels of fetuin-A (p<0.05), significant relationships between CRP and fetuin-A (rho=0.530, p<0.01), CRP and chemerin (rho=0.543, p<0.01), CRP and age (rho=0.590, p<0.001), osteopontin and fetuin-A (r=-0.415, p<0.05), chemerin and PASI score (rho=-0.424, p<0.05). We confirmed specific roles of the biomarkers in psoriasis. CRP, fetuin-A and osteopontin could be considered appropriate markers for the detection of early stages of cardiovascular diseases.

MeSH terms

  • Adult
  • Biomarkers
  • Body Mass Index
  • C-Reactive Protein / analysis*
  • Case-Control Studies
  • Chemokines / blood*
  • Female
  • Heart Disease Risk Factors*
  • Humans
  • Male
  • Middle Aged
  • Osteopontin / blood*
  • Psoriasis / complications*
  • alpha-2-HS-Glycoprotein / analysis*

Substances

  • AHSG protein, human
  • Biomarkers
  • Chemokines
  • RARRES2 protein, human
  • SPP1 protein, human
  • alpha-2-HS-Glycoprotein
  • Osteopontin
  • C-Reactive Protein