Clinical and Molecular Properties of Human Immunodeficiency Virus-Related Diffuse Large B-Cell Lymphoma

Pedro S de Carvalho; Fabio E Leal; Marcelo A Soares

doi:10.3389/fonc.2021.675353

Clinical and Molecular Properties of Human Immunodeficiency Virus-Related Diffuse Large B-Cell Lymphoma

Front Oncol. 2021 Apr 29:11:675353. doi: 10.3389/fonc.2021.675353. eCollection 2021.

Authors

Pedro S de Carvalho¹, Fabio E Leal¹, Marcelo A Soares^{1

2}

Affiliations

¹ Programa de Oncovirologia, Instituto Nacional do Câncer, Rio de Janeiro, Brazil.
² Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Abstract

Non-Hodgkin lymphoma is the most common malignancy affecting people living with HIV (PLWH). Among its several subtypes, diffuse large B-cell lymphoma (DLBCL) is an important manifestation within the HIV-infected compartment of the population. Since HIV is able to modulate B cells and promote lymphomagenesis through direct and indirect mechanisms, HIV-related DLBCL has specific characteristics. In this review, we address the clinical and molecular properties of DLBCL disease in the context of HIV infection, as well as the mechanisms by which HIV is able to modulate B lymphocytes and induce their transformation into lymphoma.

Keywords: ABC; DLBCL; GCB; HIV; NHL; PLWH.

Publication types

Review