Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Clin Infect Dis. 2022 Mar 1;74(4):715-718. doi: 10.1093/cid/ciab465.

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).

Keywords: COVID-19; SARS-CoV-2 antigens; immune responses; mRNA vaccine; spike.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2019-nCoV Vaccine mRNA-1273*
  • Antibodies, Viral
  • COVID-19 Vaccines
  • COVID-19* / prevention & control
  • Humans
  • Immunoglobulin A
  • SARS-CoV-2* / genetics
  • Spike Glycoprotein, Coronavirus / blood
  • Spike Glycoprotein, Coronavirus / genetics

Substances

  • Antibodies, Viral
  • COVID-19 Vaccines
  • Immunoglobulin A
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • 2019-nCoV Vaccine mRNA-1273