Single-Cell Epigenomics and Functional Fine-Mapping of Atherosclerosis GWAS Loci

Circ Res. 2021 Jul 9;129(2):240-258. doi: 10.1161/CIRCRESAHA.121.318971. Epub 2021 May 24.

Abstract

[Figure: see text].

Keywords: atherosclerosis; coronary artery disease; genetics; genome-wide association study; myocardial infarction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cells, Cultured
  • Chromatin Immunoprecipitation Sequencing
  • Coronary Artery Disease / genetics*
  • Coronary Artery Disease / metabolism
  • Coronary Artery Disease / pathology
  • DNA Methylation*
  • Endothelial Cells / metabolism*
  • Endothelial Cells / pathology
  • Epigenesis, Genetic*
  • Epigenome*
  • Epigenomics*
  • Female
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Humans
  • Lymphocytes / metabolism
  • Lymphocytes / pathology
  • Macrophages / metabolism
  • Macrophages / pathology
  • Male
  • Middle Aged
  • Myocytes, Smooth Muscle / metabolism*
  • Myocytes, Smooth Muscle / pathology
  • Phenotype
  • Plaque, Atherosclerotic*
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • RNA-Seq
  • Single-Cell Analysis*